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Objoon Trachoo

Objoon Trachoo, MD., PhD., FIBMS (UK)

College of Health Sciences

Clinical Associate Professor cum Chair of Medical Genetics, Medical Doctor Program

Biography

Dr. Objoon Trachoo is an experienced clinical geneticist dedicated to supporting patients and families with genetic conditions. He graduated with first-class honors from Mahidol University, Thailand, in 2000. He then completed rigorous research training in Medical Genetics and a residency in Internal Medicine at Ramathibodi Hospital, Bangkok. Dr. Trachoo further specialized by obtaining his Diplomate of the Thai Board of Internal Medicine and a PhD from the University of Sheffield, UK, in 2010.

In recognition of his contributions to medical genetics, Dr. Trachoo received the European Diploma in Medical Genetics and Genomics from the European Union of Medical Specialists and the European Board of Medical Genetics in 2019. He was also nominated as a Fellow of the Institute of Biomedical Science in the UK in 2020.

Dr. Trachoo’s training includes valuable experiences as a visiting clinical fellow in clinical genetics at Oxford Churchill Hospital and St. George’s Hospital in London. He also gained expertise in the molecular diagnosis of hemoglobinopathy at the Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.

Before joining VinUniversity, Dr. Trachoo spent 14 years as a clinical academic at Ramathibodi Hospital, Mahidol University, one of the top medical schools in Thailand. His extensive experience combines clinical practice and academia, including clinical teaching and patient care. He played a key role in the Internal Medicine Residency program, served on the postgraduate committee, and led academic affairs, curriculum development, and admission procedures. Dr. Trachoo also founded the PhD in Translational Medicine Program at Mahidol University. He significantly contributes to genetics and genomics education, sharing his expertise with tertiary education institutions and the genomic industry across Thailand and Asia.

Dr. Trachoo led multidisciplinary genetics teams in academic and private sectors in Bangkok, overseeing clinical genetics services in areas such as hemoglobinopathy, neurogenetics, neurodevelopmental disorders, inherited cardiovascular conditions, cancer genetics, genetics of sensory organ impairment, rare and undiagnosed diseases, preimplantation and prenatal genetic diagnosis. His research, which includes numerous publications, spans various genetic domains. Several of his research findings have been translated to real-life clinical practice. For example, he has developed assays for spinal muscular atrophy and congenital adrenal hyperplasia carrier screening, created efficient protocols for preimplantation genetic diagnosis for monogenic disorders, and discovered many genetic conditions among undiagnosed diseases. Meanwhile, Dr. Trachoo actively reviews manuscripts for international journals like Clinical Genetics, Prenatal Diagnosis, Molecular Cytogenetics, Developmental Medicine and Child Neurology, BMJ Open Sport and Exercise Medicine, and Clinical Case Reports.

Additionally, he is an active member of the British Society of Genetic Medicine and the European Society of Human Genetics. He also contributes as a professional member to the UK charity UNIQUE (Understanding Rare Chromosome and Gene Disorders) and volunteers as a consultant for patient support groups in Thailand, including those for Marfan syndrome and Leber’s Congenital Amaurosis.

Dr. Trachoo is eager to bring his expertise to VinUniversity and the Vinmec Healthcare system, where he plans to integrate medical genetics and genomics into clinical practice and medical education in Vietnam. He aims to collaborate with various clinical specialties and train future healthcare professionals, with the ultimate goal of establishing a robust medical genetics program in Vietnam and advancing genomics research using local resources.

Hemoglobinopathy, neurogenetics, cardiomyopathy, aortopathy, chromosomal disorders, reproductive genetics and fetal medicine

  1. Suphatsathienkul P, Sakpichaisakul K, Wechapinan T, Trachoo O, Virawan S, Wanitphakdeedecha R. Successful Treatment of Schwartz-Jampel Syndrome with Botulinum Toxin Type A. Dermatol Ther (Heidelb). 2024;14(2):545-56.
  2. Sakpichaisakul K, Boonkrongsak R, Lertbutsayanukul P, Iemwimangsa N, Klumsathien S, Panthan S, Trachoo O. Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high-dose prednisolone therapy. BMC Neurol 2022; 22: 461.
  3. Trachoo O, Yingchoncharoen T, Ngernsritrakul T, Iemwimangsa N, Panthan B, Klumsathian S, Srisukh S, Mukdadilok A, Phusanti S, Charoenyingwattana A, Chareonsirisuthigul T, Chantratita W, Tangcharoen T. Genomic findings of hypertrophic and dilated cardiomyopathy in a Thai clinical genetics service. PLoS One 2022; 17(9): e0267770.
  4. Duangchan T, Tawonsawatruk T, Angsanuntsukh C, Trachoo O, Hongeng S, Kitiyanant N, Supokawej A. Amelioration of osteogenesis in iPSC-derived mesenchymal stem cells from osteogenesis imperfecta patients by endoplasmic reticulum stress inhibitor. Life Sci 2021; 278: 119628.
  5. Satirapod C, Sukprasert M, Panthan B, Charoenyingwattana A, Chitayanan P, Chantratita W, Choktanasiri W, Trachoo O, Hongeng S. Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: a retrospective review from a single center. PLoS One 2019; 14(11): e0225457.
  6. Sakpichaisakul K, Saengow VE, Suwanpratheep P, Rongnoparat K, Panthan B, Trachoo O. Novel PANK2 mutation discovered among South East Asian children living in Thailand affected with pantothenate kinase associated neurodegeneration. J Clin Neurosci 2019; 66: 187-90.
  7. Kantaputra PN, Smith LJ, Casal ML, Kuptanon C, Chang YC, Nampoothiri S, Paiyarom A, Veerasakukwong T, Trachoo O, Ketudat Cairns JR, Chinadet W, Tanpaiboon P. Oral manifestations in patients and dogs with mucopolysaccharidosis type VII. Am J Med Genet A 2019; 179(3): 486-93.
  8. Chaivanit P, Yongsiri S, Dinchuthai P, Trachoo O. Impact of SLC47A1 (rs2289669 G>A) variant on metformin lactic acidosis patients. J Med Assoc Thai 2018; 101(9): 1163-8.
  9. Korpaisarn S, Trachoo O, Panthan B, Aroonroch R, Suvikapakornkul R, Sriphrapradang C. A novel PRKAR1A mutation identified in a patient with isolated primary pigmented nodular adrenocortical disease. Case Rep Oncol 2017; 10(2): 769-76.
  10. Pibalyart S, Trachoo O. Clinical course over five decades of a woman carrying 16p13.3 microduplication. Clin Dysmorphol 2017; 26(4): 217-20.
  11. Mukda E, Trachoo O, Pasomsub E, Tiyasirichokchai R, Iemwimangsa N, Sosothikul D, Chantratita W, Pakakasama S. Exome sequencing for simultaneous mutation screening in children with hemophagocytic lymphohistiocytosis. Int J Hematol 2017; 106(2): 282-90.
  12. Trachoo O, Satirapod C, Panthan B, Sukprasert M, Charoenyingwattana A, Chantratita W, Chokthanasiri W, Hongeng S. First successful trial of preimplantation genetic diagnosis for pantothenate kinase associated neurodegeneration. J Assist Reprod Genet 2017; 34(1): 109-16.
  13. Kamseng P, Trakulsrichai S,Trachoo O, Yimniam W, Panthan B, Jittorntam P, Niparuck P, Sanguanwit P, Wananukul W, Jindadamrongwech S. Low oxygen saturation and severe anemia in compound heterozygous Hb Louisville [β42(CD1)Phe→Leu] and Hb La Desirade [β129(H7)Ala→Val]. Hematology 2017; 22(2): 114-8.
  14. Trachoo O, Jittorntam S, Pibalyart S, Kajanachumphol S, Suvachittanont N, Patputthipong S, Chuengsaman P, Nongnuch A. Screening of Fabry disease in patients affected by end-stage renal disease of unknown etiology: the first Thailand study. J Biomed Res 2016; 31(1): 17-24.
  15. Trakulsrichai S, Panthan B, Jittorntam P, Niparuck P, Sriapha C, Chantratita W, Wananukul W, Trachoo O. First identification of hemoglobin Lansing-Ramathibodi [α87(F8)His → Gln; CAC>CAG (HBA1: c.264C>G)] in a Thai family with spurious hypoxemia. Southeast Asian J Trop Med Public Health 2016; 47(5): 1048-1054.
  16. Sriphrapradang C, Thewjitcharoen Y, Chanprasertyothin S, Nakasatien S, Himathongkam T,Trachoo O. A novel mutation in thyroid peroxidase gene causing congenital goitrous hypothyroidism in a German-Thai Patient. J Clin Res Pediatr Endocrinol 2016; 8(2): 241-5.
  17. Pitipakorn U, Suwannalai P, Trachoo O, Rattanasiri S, Chitphuk S, Ngamjanyaporn P, Sura Angiotensin-converting enzyme gene polymorphism in Thai patients with systemic lupus erythematosus. Int J Rheumatol Dis. 2016; 19(7): 693-9.
  18. Sriphrapradang C, Sornmayura P, Chanplakorn N, Trachoo O, Sae-Chew P, Aroonroch R. Fine-needle aspiration cytology of parathyroid carcinoma mimic hürthle cell thyroid neoplasm. Case Rep Endocrinol 2014; 2014: 680876.
  19. Jittorntam P, Pibalyart S, Kajanachumphol S, Suvachittanont N, Nongnuch A, Trachoo O. Establishment of biochemical screening for Fabry disease in Ramathibodi Hospital using dried blood spot and fluorometry assay. Rama Med J 2014; 37(4): 183-91.
  20. Tanprom P, Trachoo O. Building up a standard physical measurement database in healthy medical students and postgraduate medical trainees: a tool for clinical evaluation of adult dysmorphology. Rama Med J 2014; 37(4): 192-200.
  21. Srisukh S, Trachoo O, Tanhcharoen T. Etiologies of dilated cardiomyopathy in patients manifested with congestive heart failure in Ramathibodi Hospital. Rama Med J 2014; 37(4): 176-82.
  22. Trachoo O, Tangcharoen Hypertrophic cardiomyopathy: from genes to bedside. Rama Med J 2014; 37(3): 153-60.
  23. Trachoo O, Assanatham M, Jinawath N, Nongnuch A. Chromosome 20p inverted duplication deletion identified in a Thai female adult with mental retardation, obesity, chronic kidney disease and characteristic facial Eur J Med Genet 2013; 56(6): 319-324.
  24. Korpaisarn S, Trachoo O, Sriphrapradang C. Chromosome 22q11.2 deletion syndrome presenting as adult onset hypoparathyroidism: clues to diagnosis from dysmorphic facial features. Case Rep Endocrinol 2013; 2013:802793.
  25. Tawonsawatsuk T, Changthong T, Pingsuthiwong S, Trachoo O, Sura T, Wajanavisit A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population. J Orthop Surg Res 2011; 6(1); 47.
  26. Eu-ahsunthornwattana J, Trachoo O, Dejsuphong D, Tunteeratum A, Srichan K, Sura Noonan syndrome, metabolic syndrome, and stroke-in-the-young: coincidence, causal or contribution? J Med Assoc Thai 2010; 93(9): 1084-1087.
  27. Sura T, Eu-ahsunthornwattana J, Youngcharoen S, Busabaratana M, Dejsuphong D, Trachoo O, Theerasasawat S, Tunteeratum A, Noparutchanodom C, Tunlayadechanont S. Frequencies of spinocerebellar ataxia subtypes in Thailand: window to the population history? J Hum Genet 2009; 54(5): 284-88.
  28. Kanechorn Na Ayuthaya R, Patthamapasphong N, Sura T, Niumpradit N, Trachoo O. Ehlers-Danlos syndrome type IV with gastric adenocarcinoma. J Med Assoc Thai 2008; 91 Suppl 1: S166-71.
  29. Sura T, Busabaratana M, Youngcharoen S, Wisedpanichkij R, Viprakasit V, Trachoo Haemoglobin Hope in a Northern Thai Family: first identification of homozygous haemoglobin Hope associated with haemoglobin H disease. Eur J Haemotol 2007; 79(3): 251-4.
  30. Sura T, Trachoo O, Viprakasit V, Vathesatogkit P, Tunteeratum A, Busabaratana M, Wisedpanichkij R, Isarangkura Hemoglobin H disease induced by the common SEA deletion and the rare hemoglobin Quong Sze in a Thai female: longitudinal clinical course, molecular characterization and development of a PCR-RFLP based detection method. Ann Hematol 2007; 86(9): 659-63.
  31. Trachoo O, Sura T, Sakuntabhai A, Singhasivanon P, Krudsood S, Phimpraphi W, Krasaesub S, Chanjarunee S, Looareesuwan S. Molecular characterization of hereditary persistence of fetal hemoglobin in the Karen people of Thailand. Hemoglobin 2003; 27(2): 97-104.
  32. Trachoo O, Rivolta MN. Neural differentiation of human embryonic stem cells and their potential application in a therapy for sensorineural hearing loss. In: Baharvand H. (ed). Trends in Stem Cell Biology and Humana Press, 2009: 261-82.

 

  • European Diploma in Medical Genetics and Genomics (EDMGG), 2019
  • PhD in Biomedical Sciences, University of Sheffield, United Kingdom, 2010
  • Diplomate of the Thai Board of Internal Medicine, 2006
  • Doctor of Medicine with the first-class honor, Ramathibodi Hospital, Mahidol University, Thailand, 2000

  • Fellowship of the Institute of Biomedical Science (FIBMS), United Kingdom, 2020
  • Finalist for the UK Alumni Award, British Council, Thailand, 2016
  • Educational Award of Excellence in Science and Medicine, the Anglo-Thai Society, UK, 2009
  • Internal Medicine Resident Excellence Award, Ramathibodi Hospital, in three consecutive years, 2003-2005
  • Medical Intern Excellence Award, Uttaradit Hospital, 2001

PROFESSIONAL AFFILIATIONS

  • British Society for Genetic Medicine
  • European Society of Human Genetics
  • Institute of Biomedical Science, UK
  • Royal College of Physician of Thailand
  • The Medical Council of Thailand