A New Generation of Targeted Therapies for Cancer, Autoimmune, and Infectious Diseases

Speaker: Dr. Philip S. Low, Presidential Scholar for Drug Discovery & Ralph C. Corley Distinguished Professor of Chemistry – Biochemistry, Department of Chemistry, Purdue University

Monday, May 30, 2022 | 4.30 – 5.30 pm (Hanoi time)
Ball-Room G104 | Zoom Meeting

Abstract: We are exploring the use of high affinity targeting ligands to deliver attached drugs specifically into diseased cells, thereby simultaneously improving their potencies and reducing their off-target toxicities. For this purpose, we have designed targeting ligands for many human cancers, viruses and virus-infected cells, bone fracture surfaces, inflammatory macrophages, regulatory T cells, cancer associated fibroblasts, myeloid derived suppressor cells, antigen presenting cells, and tumor associated fibroblasts among others. Our tumor-targeted fluorescent dyes (one FDA-approved, two in clinical trials) are beginning to revolutionize cancer surgeries by enabling surgeons to find far more malignant lesions than previously possible. Our PSMA-targeted DOTA conjugate (177Lu-PSMA-617; phase 3 completed; awarded Breakthrough Status) has generated more than 40% response rates in refractory metastatic castration-resistant prostate cancer, offering hope for patients with previously untreatable tumors. Our tumor associated macrophage-targeted TLR7 agonists and regulatory T cell targeted immune stimulants enable the suppression of growth of nearly all solid tumors, and our universal CAR T cell therapies (clinical trials in 2022) have repeatedly shown an ability to eradicate solid tumors in animals. Our recently launched bone fracture-targeted anabolic agents (clinical trials in 2022) are reducing fracture healing times in animals by more than 60% while generating repaired bone that is stronger than healthy bone, and our fibroblast activation protein-targeted PI3K inhibitor (preclinical) is halting fibrosis in animal models of fibrotic diseases. Our influenza-targeted immunotherapy is 80X more potent than Tamiflu, and similar targeted immunotherapies for other viral diseases are undergoing development. Finally, our therapy for malaria (phase 3 clinical trials in SE Asia) is eliminating parasitemia in all patients in <3 days, and our nontoxic treatment for sickle cell disease (phase 1 clinical trials) shows promise for alleviating the causes of SCD. In my seminar, I will briefly summarize the structures, biological activities, preclinical data and clinical results (where available) for each of these therapies.

Bio: Dr. Philip S. Low is the Presidential Scholar for Drug Discovery and the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University.  Dr. Low has spent over 35 years designing targeted imaging and therapeutic agents for the diagnosis and treatment of many human diseases. Included among the diseases for which he has developed therapies are malaria, multiple cancers, sickle cell disease, idiopathic pulmonary fibrosis, bone fractures, rheumatoid arthritis, and several virus infections. Seven drugs from Low’s research are currently undergoing human clinical trials, one of which (Cytalux) was approved by the FDA in November 2021 and a second (Pluvicto; Lu-PSMA-617) received “Breakthrough Therapy Status” from the FDA and was approved in March 2022.  To accelerate development of his drugs, Low has founded seven successful companies (Endocyte Inc., OnTarget Laboratories Inc., Umoja Biopharma, Morphimmune Inc., Novosteo Inc., Eradivir Inc. and ErythroCure Inc.). Low has published over 550 scientific articles (H-index of 115) and has over 200 US patents/patents pending. Low has also been recognized with many national and international awards, including the AACR Award for Chemistry in Cancer Research, the ACS Award for Cancer Research (Sosnovsky Award), an NIH MERIT Award and the ACS Award (Esselen Award) for Chemistry in the Public Interest among others. In his spare time, Low likes skiing, hiking, golfing and playing with his grandkids. Dr. Low received his B.S. in Chemistry from BYU (1971) and his Ph.D. in Biochemistry from UCSD (1975).

Organic Solar Cells and the Future Energy Challenge

Speaker: Thuc-Quyen Nguyen, Professor, Department of Chemistry & Biochemistry; Director, Center for Polymers and Organic Solids; University of California, Santa Barbara (UCSB)

Friday, April 22, 2022, 8 am- 9 am | Zoom Meeting

Abstract: The development of alternative energy sources is now recognized by government, society and the global community as an urgent need. Solution-processed organic solar cells potentially offer low cost, large area, flexible, and light-weight alternative energy sources for indoor and outdoor applications. These devices are based on organic semiconductors, a class of carbon-based materials that can be synthesized to have band gaps from the UV to the near infrared regions of the electromagnetic spectrum. Organic semiconductors are attractive due to their unique properties: light weight, mechanical flexibility, low cost, low-temperature processing, and simple fabrication methods from solution such as roll-to-roll coating, spray coating or ink-jet printing into desired size and shape. Such materials are expected to form the basis of new technologies — called the Organic Electronics. OSCs have been implement in commercial products such as displays and lightings and have potential applications in transistors, solar cells, photodetectors, thermoelectrics, ratchets, sensors, neuromorphic computing, and bioelectronics. In this talk, I will discuss the future energy challenge, the development of organic solar cells, and their potential applications in building integration and greenhouses.

Bio: Thuc-Quyen Nguyen is the Director of the Center for Polymers and Organic Solids (CPOS) and professor in the Department of Chemistry & Biochemistry at the University of California, Santa Barbara (UCSB). Professor Nguyen received her B.S., M.S., and Ph.D. degrees in Physical Chemistry from the University of California, Los Angeles. From 2001-2004, she was a research associate in the Department of Chemistry and the Nanocenter at Columbia University working with Professors Louis Brus and Colin Nuckolls on molecular self-assembly, nanoscale characterization and devices. She also spent time at IBM Research Center at T. J. Watson (Yorktown Heights, NY) working with Richard Martel and Phaedon Avouris on molecular electronics. She joined the faculty of the Chemistry and Biochemistry Department at UCSB in July 2004. She is co-authored 278 publications and 3 book chapters that received over 32,000 citations and gave over 290 plenary/keynote/invited talks at national and international conferences, universities, and companies. Recognition for her research includes the 2005 Office of Naval Research Young Investigator Award, the 2006 National Science Foundation CAREER Award, the 2007 Harold Plous Award, the 2008 Camille Dreyfus Teacher Scholar Award, the 2009 Alfred Sloan Research Fellows, the 2010 National Science Foundation American Competitiveness and Innovation Fellows, the 2015 Alexander von Humboldt Senior Research Award, the 2016 Fellow of the Royal Society of Chemistry, the 2019 Hall of Fame – Advanced Materials, the 2019 Beaufort Visiting Scholar, St John’s College, Cambridge University, the 2015-2019 World’s Most Influential Scientific Minds; Top 1% Highly Cited Researchers in Materials Science by Thomson Reuters and Clarivate Analytics, the 2019 Fellow of the American Association for the Advancement of Science (AAAS), the Stanford University’s 2020 list of the World Top 2% Highly Cited Scientists, the 2020 UCSB Outstanding Graduate Student Mentor Award, and the 2021 Women in Materials Science by Advanced Materials. Her current research interests are doping in organic semiconductors, charge transport in organic semiconductors, bioelectronics, and device physics of organic solar cells, ratchets, transistors, and photodetectors.

Abstract: COVID-19 spread across the world with a speed and intensity that laid bare the limits in our understanding of the transmission pathways of such respiratory diseases. After much confusion and misinformation, there emerged a consensus that airborne transmission from very small respiratory droplets is the most important route for the spread of COVID-19. Each stage in this transmission pathway is mediated by complex flow phenomena, ranging from air-mucous interaction inside the respiratory tract, turbulence in the exhaled jet/ambient flow, to inhalation and deposition of these aerosols in the lungs. Given the emergence of the Delta-variant and the resurgence of infections in many communities, the importance of communicating infection risk across scientific disciplines, as well as to policy/decision makers, is more important than ever. Inspired by the Drake Equation that provides a framework to estimate the seemingly inestimable probability of advanced extraterrestrial life, we propose a relatively simple model for estimating the risk of airborne transmission of a respiratory infection such as COVID-19. The model incorporates simple ideas from fluid dynamics with known factors involved in airborne transmission and is designed to serve not only as a common basis for scientific inquiry across disciplinary boundaries, but also be understandable by a broad audience outside science and academia.

Bio: Rajat Mittal is Professor of Mechanical Engineering at the Johns Hopkins University (JHU) with a secondary appointment in the School of Medicine. He received the B. Tech. degree from the Indian Institute of Technology at Kanpur in 1989, and the Ph.D. degree in Applied Mechanics from The University of Illinois at Urbana-Champaign, in 1995. His research interests include fluid mechanics, computing, biomedical engineering, biofluids and flow control. He is the recipient of the 1996 Francois Frenkiel Award from the Division of Fluid Dynamics of the American Physical Society, and the 2006 Lewis Moody, and the 2021 Freeman Scholar awards from the American Society of Mechanical Engineers. He is a Fellow of American Society of Mechanical Engineers and the American Physical Society, and an Associate Fellow of the American Institute of Aeronautics and Astronautics. He is associate editor of the Journal of Computational Physics, Frontiers of Computational Physiology and Medicine, and the Journal of Experimental Biology, and on the editorial boards of the International Journal for Numerical Methods in Biomedical Engineering, and Fluids (an MDPI journal).

April 14, 2021, 5:00 – 6:00PM

Speaker:

Brenda Lynn Dietrich Arthur and Helen Geoffrion Professor of Practice in the School of Operations Research. Member of Board of Trustees for the Institute for Pure and Applied Mathematics. Member, Governing council of the NAE, Member of the National Research Council Board on Science, Technology, and Economic Policy Previously, in her 33 years of distinguished career at IBM, Dr. Dietrich served in many leadership roles, including: – Head of the Mathematical Sciences function in the IBM Research division. – IBM Fellow in 2007, and Vice President in 2008 – Chief Technology Officer and Strategist for IBM’s Business Analytics group.

Riding Data Waves: From Ripples to Tsunamis

The 2010s were arguably been the decade of data, with “big data“ becoming bigger, data-driven decision making becoming a corporate imperative, data analytics becoming the hot new degree, data being called a natural resource, and data scientist being awarded the dubious title of “sexiest job of the 21st century.” In many ways, the focus on data was just the next logical and inevitable stage in the evolution of information technology; it required the previous stages and it will provide the foundation for future evolution. In this talk, a quick history of the past six decades of IT will be reviewed with a focus on the digitization of data and the creation of new data by-products. A brief detour will be a discussion of technology projections made in 1995, including what happened, what happened much later than projected, what was projected that didn’t happen, and what happened that was largely unforeseen. The talk will resume with examples of current and emerging use and creation of data and will conclude with a view of future possibilities for the current decade, technical and non-technical issues that may accelerate or delay the possibilities, and some musings on methods to defend first-principals driven methods from displacement by purely data-driven approaches.

January 27, 2021, 5:00 – 6:00PM

Speaker:

Glen Gaulton Vice Dean and Director of Global Health Professor, Department of Pathology and Laboratory Medicine Director, Center for Global Health  University of Pennsylvania Perelman School of Medicine Member, Academic Advisory Board, VinUniversity See the detailed biography here.

The Critical Role of Biomedical Research in Driving Innovations that Improve Health Outcomes

Dr. Gaulton’s talk will focus on the importance of the junction between university-based scholarship and patient clinical care in driving innovations that improve health outcomes.  Using real-world examples, he will illustrate how these measures bridge research across the university and unite faculty, staff and trainees in a common higher purpose for the public good.

Dr. Gaulton is Professor of Pathology and Laboratory Medicine at the University of Pennsylvania, Perelman School of Medicine, and is Vice Dean and Director of the Center for Global Health. He is also Project Director of the VinUni-Penn Alliance. His research spans virology and immunology, and he has held multiple local/national leadership positions over a 35+ year career.

2020 Distinguished Lecture Series

November 25, 2020

Prof. Mark Campbell

Autonomous, self-driving cars have the potential to impact society in many ways, including taxi/bus service; shipping and delivery; and commuting to/from work. This talk will give an overview of the history, technological work to date and challenges, and potential future impact of self-driving cars. A key challenge is the ability to perceive the environment from the cars sensors, i.e. how can a car convert pixels from a camera, to knowledge of a scene with cars, cyclist, and pedestrians. This perceived information is typically uncertain, constantly being updated, yet must also be used for important decisions by the car, ranging from a simple change to lanes, or stopping and queuing at a traffic light. Videos, examples, and insights will be given of Cornell’s autonomous car, as well as key performers such as Google/Waymo and car companies. We can then hypothesize together of how our future will look as this amazing technology continues to unfold!

December 9, 2020

Changes in Most Essential Lifeline: The Food Supply Chain

The coronavirus pandemic has highlighted, many times over, the complex and vital role that the food supply chain plays in meeting the basic needs of consumers around the world.  Changes in consumer buying patterns, food production, distribution bottlenecks and new governmental restrictions have added immeasurably to the challenges of bringing food to households.  This seminar will discuss the functioning of the global food system and the disruptions that have beset it as a result of the pandemic.  Various outcomes for the future of the food supply chain, food companies and consumers will be explored.

December 12, 2020 – January, 2021

Speaker:

Joseph Halpern Professor of Computer Science Joseph C. Ford Professor of Engineering Cornell College of Engineering Professor of Mathematics Cornell College of Arts and Science See the detailed biography at Cornell Business faculty’s page.

VinUniversity and CECS are pleased to announce a lecture series by Professsor Joseph Halpern from Cornell University who is an expert on the logic behind the math of everyday events.

This 3-part lecture series includes some fascinating insights on game theory, the uncertainty that rules our daily life and to which extent common knowledge affects our decisions. The talks are appropriate for a general audience since it does not require knowledge in mathematics. Thus, whether a high school or university student, or a distinguished professor, everyone will learn something new. The only thing you need to bring with you is your curiosity. Part of the talk is interactive, so you will have the chance to actively participate, in an effort to give answers to fundamental philosophical and practical questions.

1. Knowledge and common knowledge in multi-agent systems

Time: 9:00AM, December 12, 2020

2. Using Multi-Agent Systems to Represent Uncertainty

Time: 8:00PM, December 18, 2020

3. Actual Causality: A Survey

Time:  January 2021 (exact date TBD)

December 16, 2020

Integrating Teaching, Research, and Industry Relations for Synergy and Relevance 

The aim of this talk is to develop the ideas that teaching, research and industry relations are complementary.  By industry relations, I mean interacting with industry, selecting research problems of interest to industry, and writing for the industry audience. I will use two personal examples of the linkage between the three areas. The first example, in the domain of workforce scheduling, developed from my dissertation and main research agenda pre-tenure.  That lead to a complex scheduling black-box program I created for a large hospitality company, a primer series of four industry-oriented reports, and to material that I still use in class.  The second example, restaurant operations optimization, was driven by an Excel®-based simulation model I created for an undergraduate class.  The evolved into a research tool which lead to 13 academic papers and 9 industry-focused reports and tools.  I will show a short demo of the current version of the teaching simulator, which continues to evolve as students use it in class.