Home News 3D imaging of cells and tissues using polarized light microscopy

3D imaging of cells and tissues using polarized light microscopy

Abstract

While polarized light and polarized fluorescence imaging are widely used as imaging tools in biological studies, it is still impossible to reveal the full, 3-dimensional anisotropy using available imaging techniques. To overcome this problem, the Oldenbourg lab at Marine Biological Laboratory, Woods Hole, MA, USA, first developed the Light Field LC-PolScope, which combines the LC-PolScope and light-field imaging [Oldenbourg, 2008, Tran, 2018]. This novel microscope for 3D birefringence/fluorescent anisotropy imaging will allow full orientational order to be mapped in three dimensions. This instrument will free biological polarized light microscopy from the constraint of two dimensions and enable its application to living cells and tissues. We will replicate and further develop Light Field LC-PolScope to fit our research goals at our laboratory at VinUni. Furthermore, we will use LC-PolScope and the Light Field LC-PolScope for biological and material science applications.

Author: Mai Tran

Read more about the author’s publications here

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