Than Thi Trang Uyen, Dr
College of Health Sciences
Assistant Professor
Central Lab
Director
Email:
uyen.ttt@vinuni.edu.vn
Biography
Dr. Than Thi Trang Uyen received her BSc and MSc in Cytology from VNU–Hanoi University of Science (Vietnam) in 2003 and 2007, respectively, and a PhD in Biomedical Science from Queensland University of Technology (Australia) in 2017. She joined Vinmec in 2017, has been with VinUni since 2024, and serves as Central Lab Director at the Vinmec–VinUni Institute of Immunology. Her research focuses on the application of extracellular vesicles in regenerative medicine, including the development of products for skin rejuvenation, hair growth, and osteoarthritis treatment. Several of her products are currently in use within the Vinmec Healthcare System for skin rejuvenation.
At present, she is developing exosomes as drug-delivery systems—loading therapeutic agents into exosomes, conjugating targetable peptides onto exosomal membranes, and embedding exosomes in hydrogels to achieve controlled release.
Mesenchymal stem cells, exosomes, regenerative medicine, drug delivery.
Biology, Cytology
1. Tong TH, Do XH, Nguyen TT, Pham BH, Le QD, Nguyen XH, Hoang NTM, Nguyen TH, Nguyen NH, Than UTT. Umbilical cord blood-derived platelet-rich plasma as a coating substrate supporting cell adhesion and biological activities of wound healing. Eur J Med Res. 2025 Feb 28;30(1):145.
2. Thi Trang Uyen, Than; Hoang, Dao Huy. Exosomes Support the Viability of Mesenchymal Stem Cells in the Storage Condition of 4 oC. VNU Journal of Science: Natural Sciences and Technology, [S.l.], June 2025. ISSN 2588-1140. doi: https://doi.org/10.25073/2588-1140/vnunst.5813.
3. Dao HH, Nguyen TH, Hoang DH, Vu BD, Tran MA, Le MT, Hoang NTM, Bui AV, Than UTT, Nguyen XH. Manufacturing exosomes for wound healing: Comparative analysis of culture media. PLoS One. 2024 Nov 14;19(11):e0313697. doi: 10.1371/journal.pone.0313697.
4. Quynh DT, Trang Uyen TT, My Nhung HT, Hoang Tung D, Thu Huyen N, Ngoc Thanh L, Thom VT, Bich Phuong LT, Manh Ha N. Wound healing capacity of using mesenchymal stem cell-derived exosomes originated from human adipose tissue and cold atmospheric plasma. Clin Ter. 2024 Mar-Apr;175(2):135-143. doi: 10.7417/CT.2024.5046.
5. Nguyen LT, Do XH, Pham HB, Duy-Thanh D, Than UTT, Nguyen TH, Nguyen VB, Le DS, Nguyen DT, Kieu KT, Nguyen PT, Vu MD, Tran NT, Nguyen TL, Nghiem LTH, Nguyen TD, Nguyen NTH, Hoang NM. Different Biocompatibility and Radioprotective Activity of Squid Melanin Nanoparticles on Human Stromal Cells. ACS Omega. 2024 Aug 22;9(35):36926-36938.
6. Thân Thị Trang Uyên, Nguyễn Thị Tuyết Anh, Hoàng Hương Diễm. Ảnh hưởng của loại tế bào gốc trugn mô và lần cấy chuyển đến hàm lượng protein exosome được tiết ra. Procedings, National Biotechnology Conference 2024
7. Thân Thị Trang Uyên, Lê Thị Huyền, Phạm Thị Phương. Ảnh hưởng của môi trường lên khả năng tăng sinh và chức năng tế bào giết tự nhiên in vitro. Procedings, National Biotechnology Conference 2024
8. MINH, Nguyen Quang; DAI, Nguyen Dang; UYEN, Than Thi Trang. The Capacity of Wharton’s Jelly to Prolong the Survival of Skin Tissues ex vivo. VNU Journal of Science: Natural Sciences and Technology, [S.l.], v. 40, n. 2, apr. 2024. ISSN 2588-1140. doi: https://doi.org/10.25073/2588-1140/vnunst.5593.
9. Thân Thị Trang Uyên, Trịnh Phương Đông, Nguyễn Thu Huyền, Hoàng Hương Diễm, & Nguyễn Thanh Liêm. (2024). Phân tích biểu hiện một số cytokine và yếu tố tăng trưởng tế bào trong dịch não tủy của bệnh nhân rối loạn cơ tròn, viêm tủy cắt ngang và liệt. Bản B của Tạp Chí Khoa học Và Công nghệ Việt Nam, 66(5). https://doi.org/10.31276/VJST.66(5).01-06.
10. Than, U.T.T., Nguyen, L.T., Nguyen, P.H. et al. Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy. Sci Rep 13, 22587 (2023). https://doi.org/10.1038/s41598-023-49902-8
11. Thi Thuy Nguyen, Hoang Nam Nguyen, Thi Ha Lien Nghiem, Xuan-Hai Do, Thanh Thuy To, Thi Xuan Phuong Do, Dieu Linh Do, Huong Giang Nguyen, Huy Manh Nguyen, Ngoc Dinh Nguyen, Manh Quynh Luu, Trong Nghia Nguyen, Thi Bich Ngoc Nguyen, Van Toan Nguyen, Van Thanh Pham, Uyen Thi Trang Than, Thi My Nhung Hoang. High biocompatible FITC-conjugated silica nanoparticles for cell labeling in both in vitro and in vivo models. Sci Rep 14, 6969 (2024). https://doi.org/10.1038/s41598-024-55600-w
12. Le MT, Nguyen HT, Nguyen XH, Do XH, Mai BT, Ngoc Nguyen HT, Trang Than UT* & Nguyen TH*. Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer. Heliyon. 2023 Nov 14;9(11):e22080. doi: 10.1016/j.heliyon.2023.e22080. PMID: 38058618; PMCID: PMC10696070.
13. Do XH, Le MT, Nguyen TH, Le TT, Nguyen XH, Mai TB, Hoang TMN, Than UTT#. Detection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis. J Hepatocell Carcinoma. 2023 May 26;10:783-793. doi: 10.2147/JHC.S409649. PMID: 37260529; PMCID: PMC10228584.
14. Do Thi Quynh, Nguyen Manh Ha, Than Thi Trang Uyen, Vu Thi Thu, Dang Tran Tien, Ho My Dung. Creating A Diabetic Rat Model With Skin Wounds In Rats For Application In Wound Treatm
- Bachelor and Master at VNU-Ha Noi University of Sciences, Viet Nam
- PhD in Biomedical Sciences at Queensland University of Technology, Australia
