Andrew Sawyer, PhD
College of Health Sciences
Senior Lecturer
Biography
Dr. Andrew Sawyer received the B.Sc. degree from the University of Sydney, Australia, in 2014 and First Class Honours in 2015. He completed his Ph.D. at the University of Sydney in 2022 and subsequently worked as a Postdoctoral Research Associate at the University of Sydney until 2025. His research has focused on immunology, spatial biology, and tuberculosis pathology, with particular interest in understanding the immune microenvironment of human disease tissues. Dr. Sawyer has authored and co-authored publications in journals including the Journal of Experimental Medicine, Frontiers in Immunology, Cell Reports, and Current Protocols. He has also served as a reviewer for Frontiers in Immunology and was awarded a Research Training Program (RTP) Scholarship during his doctoral studies.
- High dimensional multiplex image analysis
- Machine learning analysis of immunopathology images
- Re-use of public image and transcriptomic data to develop new hypotheses
- Use of archival/museum specimens to understand the immunopathology of modern diseases
- Immunopathology of respiratory diseases including tuberculosis and influenza
- Nucleic acid imaging
- Multiplex immunohistochemistry
- Immunopathology of infectious diseases
- Protein and nucleic acid imaging technologies
- Tuberculosis, influenza and infectious diseases in the lung
- Image analysis using AI pipelines
1. Xiao, W., Sawyer, A.J. et al. (2025) Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis, bioRxiv 2025.04.11.648467. (Preprint).
2. Sawyer, A. J. et al (2025). Highly Adaptable Analysis Tools for Mapping Spatial Features of Cellular Aggregates in Tissues. Current Protocols, 5(5), e70135.
3. Sawyer, A. J., et al. (2023). Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis. Journal of Experimental Medicine, 220.
4. Sawyer, A. J., et al. (2021). Transcriptomic Profiling Identifies Neutrophil-Specific Upregulation of Cystatin F as a Marker of Acute Inflammation in Humans. Frontiers in Immunology, 12.
5. Stifter, S. A., Sawyer, A. J., et al. (2019). Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo. Cell Reports, 29(13), 3539–3550.e4.
- 2022: Ph.D. in Medicine from the University of Sydney
- 2015: B.Sc. Honours in immunology from the University of Sydney
- 2014: B.Sc. in Science from the University of Sydney
- 2015 Australian Government RTP PhD Scholarship
